The BED and EQD2 Calculator is being developed to support biological comparison of radiotherapy fractionation schedules. Using total dose, number of fractions and a selected tissue-specific alpha/beta ratio, the calculator will estimate the biologically effective dose and the corresponding equivalent dose delivered in 2 Gy fractions.
The tool will assist medical physicists, radiation oncologists, researchers and trainees in comparing conventional fractionation, hypofractionation and selected stereotactic treatment schedules. Separate alpha/beta ratios can be used to assess anticipated effects on tumour control and late-responding normal tissues. Calculations are based on the standard linear–quadratic model:
BED = nd × [1 + d/(α/β)]
EQD2 = BED ÷ [1 + 2/(α/β)]
where n is the number of fractions, d is the dose per fraction and α/β is the selected tissue-specific ratio.
The results are intended for education, research, preliminary comparison and independent checking. Clinical interpretation requires professional judgement, particularly for very high doses per fraction, treatment interruptions, re-irradiation and situations where the standard linear–quadratic model may have limitations.
What we can provide
- Total-dose and fraction-number inputs
- Automatic dose-per-fraction calculation
- User-defined alpha/beta ratio
- Common tissue alpha/beta presets
- Biologically effective dose calculation
- Equivalent dose in 2 Gy fractions
- Comparison of multiple fractionation schedules
- Separate tumour and normal-tissue calculations
- Cumulative BED and EQD2 assessment
- Clear formula and calculation breakdown
- Printable calculation summary